Methane → 4-Amino-6-(1-methylcyclopropyl)-3-methylthio-1,2,4-triazin-5-one

HRID 46799Notes

Reaction equation

HRID 46799 reaction equation
[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:11][CH2:10]2)=[N:5][N:4]=[C:3]1[SH:13].[CH4:14].CI>[OH-].[Na+]>[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:10][CH2:11]2)=[N:5][N:4]=[C:3]1[S:13][CH3:14]

Participants

5

Reactant 3

HCID 297MethaneHCID 6328Methyl iodideHCID 178421680HCID 178421680, compound

Product 1

HCID 204889204-Amino-6-(1-methylcyclopropyl)-3-methylthio-1,2,4-triazin-5-oneYield 82.3%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

198 grams of the compound obtained according to (b) were dissolved in 500 ml of 2 normal NaOH and treated with 500 ml of methane and 150 grams of methyl iodide. The mixture was stirred for 6 hours at 20° to 30° C. The crystals formed were filtered off with suction, washed and dried. There are obtained 174.5 grams of final product (dried in a vacuum at 40° C.), white crystals, M.P. 115° to 116° C.

Workup

  1. customThe crystals formed
  2. filtrationwere filtered off with suction
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-5466c7e1b96f44aa85af8215829ebd59
Source dataset
uspto-grants-1979_11
Patent number
US04175188

Reaction notes

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