Hydrochloric Acid → HCID 59625999, compound

HRID 468105Notes

Reaction equation

HRID 468105 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([O:19]C)=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1.[OH-].[Na+].Cl>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([OH:19])=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59625970HCID 59625970, compound

Product 1

HCID 59625999HCID 59625999, compoundYield 311.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 9u (187 mg, 0.44 mmol) was refluxed with 3N aqueous NaOH (0.25 mL mg, 0.75 mmol) in THF (6 mL) overnight. Concentrated HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was concentrated to give 9v (350 mg) as the tris-HCl salt.

Workup

  1. concentrationThe resulting mixture was concentrated

Sources & evidence

ORD record
ord-ac8d35e8e2e04420b4d2ed8b0c3cc816
Source dataset
uspto-grants-2014_01
Patent number
US08623858B2

Reaction notes

Loading…