Hydrochloric Acid → HCID 89893880, compound

HRID 468706Notes

Reaction equation

[CH3:1][C:2]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][C:3]=1[O:4][CH2:5][C:6]1[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=1[CH:8]([OH:11])[C:9]#[N:10].Cl.[OH2:22]>C1(C)C(C)=CC=CC=1>[CH3:1][C:2]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][C:3]=1[O:4][CH2:5][C:6]1[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=1[CH:8]([OH:11])[C:9]([NH2:10])=[O:22]

Participants

Conditions

Temperature: 50 °C

Procedure

To 10.0 g of 2-(2,5-dimethylphenoxymethyl)-mandelonitrile (content: 96% by weight), 30 g of xylene, 3.66 g of hydrogen chloride and 0.648 g of water were added. The obtained mixture was heated to 50° C., stirred and maintained at the same temperature for 3 hours to obtain a xylene solution containing 2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-hydroxyacetamide (yield: 65.7%). The formation of by-products generated by the hydrolysis of 2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-hydroxyacetamide was not recognized.

Workup

temperaturemaintained at the same temperature for 3 hours

Sources & evidence

ORD record: ord-f1badcf9c9e34ccb80fdc808b1ce54ab
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08624062B2

Reaction notes

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