Sodium borohydride → N-(7-(3-fluoro-2-(hydroxymethyl)-6-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide

HRID 468969Notes

Reaction equation

HRID 468969 reaction equation
[BH4-].[Na+].[F:3][C:4]1[C:5]([CH:27]=[O:28])=[C:6]([C:11]2[CH:20]=[C:19]3[C:14]([CH:15]=[C:16]([NH:21][C:22]([CH:24]4[CH2:26][CH2:25]4)=[O:23])[N:17]=[CH:18]3)=[CH:13][CH:12]=2)[C:7]([CH3:10])=[CH:8][CH:9]=1>C1COCC1.C(OCC)(=O)C>[F:3][C:4]1[C:5]([CH2:27][OH:28])=[C:6]([C:11]2[CH:20]=[C:19]3[C:14]([CH:15]=[C:16]([NH:21][C:22]([CH:24]4[CH2:25][CH2:26]4)=[O:23])[N:17]=[CH:18]3)=[CH:13][CH:12]=2)[C:7]([CH3:10])=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 86674986N-(7-(3-fluoro-2-formyl-6-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide

Product 1

HCID 67976415N-(7-(3-fluoro-2-(hydroxymethyl)-6-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamideYield 40.8%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
40 °C

Procedure

Sodium borohydride (11 mg, 0.29 mmol) was added to a solution of N-[7-(3-fluoro-2-formyl-6-methyl-phenyl)-3-isoquinolyl]cyclopropanecarboxamide (50 mg, 0.14 mmol) in THF (1 mL). The reaction mixture was heated at 40° C. for 1 hour and then diluted with ethyl acetate (40 mL) and washed with water (40 mL). The organic layer was separated, dried over sodium sulfate, filtered and concentrated in vacuo to provide a residue that was purified by reverse phase HPLC (5-85% acetonitrile in water w/0.1% NH4OH, 14 minutes). Desired fractions were combined and evaporated in vacuo to afford the title compound as an off-white solid (20 mg, 40%). 1H NMR (400 MHz, DMSO) δ 10.90 (s, 1H), 9.14 (s, 1H), 8.50 (s, 1H), 7.92 (d, J=8.5 Hz, 1H), 7.89 (s, 1H), 7.54 (dd, J=8.5, 1.4 Hz, 1H), 7.31 (dd, J=8.3, 5.8 Hz, 1H), 7.20-7.12 (m, 1H), 4.79 (t, J=4.9 Hz, 1H), 4.25-4.10 (m, 2H), 2.13-2.03 (m, 1H), 1.99 (s, 3H), 0.91-0.79 (m, 4H). LCMS (Method E): RT=4.648 min, M+H+=351.2.

Workup

  1. washwashed with water (40 mL)
  2. customThe organic layer was separated
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customto provide a residue that
  7. customwas purified by reverse phase HPLC (5-85% acetonitrile in water w/0.1% NH4OH, 14 minutes)
  8. customevaporated in vacuo

Sources & evidence

ORD record
ord-72cc20457f7f4c3fb6ef1246a6e0e36a
Source dataset
uspto-grants-2014_01
Patent number
US08623889B2

Reaction notes

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