反应详情

To 2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was added 28% w/v ammonium hydroxide solution (20 mL). The mixture was stirred overnight at ambient temperature then concentrated in vacuo. The residue was dry loaded and purified by FCC eluting with 2-10% EtOH in CHCl3 to afford 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine.

1. concentrationthen concentrated in vacuo
2. customThe residue was dry loaded
3. custompurified by FCC
4. washeluting with 2-10% EtOH in CHCl3