反应详情

5-({[(2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (465 mg, 1.3 mmol) was dissolved in DCE (40 mL) and CDI (422 mg, 2.6 mmol) was added. The reaction was stirred for 1 h. 4 mL of activated acid solution in DCE was added to a vial containing 1-[2-(pyridin-4-yl)ethyl]piperazine (50 mg, 0.261 mmol). The reaction was stirred at ambient temperature for 3 days, then washed with saturated aqueous NaHCO3. The organic layer was dried over MgSO4 and shaken with PL-MIA and Ambersep resins, then filtered. The solvent was removed in vacuo and a portion of the crude product purified using prep method B.

1. stirringThe reaction was stirred at ambient temperature for 3 days
2. washwashed with saturated aqueous NaHCO3
3. dry with materialThe organic layer was dried over MgSO4
4. stirringshaken with PL-MIA and Ambersep resins
5. filtrationfiltered
6. customThe solvent was removed in vacuo
7. customa portion of the crude product purified