Trifluoroacetic acid → HCID 58393372, compound

HRID 469014Notes

Reaction equation

HRID 469014 reaction equation
[NH:1]1[C@@H:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C@H:4]2[NH:3][CH:2]1[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18]C(=O)OC(C)(C)C)=[CH:12][CH:11]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:1]1[C@@H:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C@H:4]2[NH:3][CH:2]1[C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][NH2:18])=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86762214HCID 86762214, compound

Product 1

HCID 58393372HCID 58393372, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl (2-{4-[(3aR,7aR)-octahydro-1H-benzimidazol-2-yl]phenyl}ethyl)carbamate (50 mg, 0.15 mmol) was stirred in a 4:1 mixture of DCM:TFA (1 mL) at ambient temperature for 18 h. The reaction was concentrated in vacuo and the crude product used without further purification.

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe crude product used without further purification

Sources & evidence

ORD record
ord-0f462ca0f42e4e428b660eb1b2bed395
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

Loading…