1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 58393052, compound

HRID 469041Notes

Reaction equation

HRID 469041 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21](O)=[O:22])[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C.Cl.[CH3:56][NH:57][CH2:58][C:59]1[CH:70]=[CH:69][C:62]([CH2:63][N:64]2[CH2:67][CH:66]([OH:68])[CH2:65]2)=[CH:61][CH:60]=1>C(Cl)Cl>[OH:68][CH:66]1[CH2:65][N:64]([CH2:63][C:62]2[CH:69]=[CH:70][C:59]([CH2:58][N:57]([CH3:56])[C:21]([C:18]3[CH:17]=[C:16]([CH2:15][N:13]([S:10]([C:6]4[C:7]([CH3:9])=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=4[CH3:24])(=[O:11])=[O:12])[CH3:14])[O:20][CH:19]=3)=[O:22])=[CH:60][CH:61]=2)[CH2:67]1

Participants

7

Reactant 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acidHCID 67217323HCID 67217323, compound

Product 1

HCID 58393052HCID 58393052, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared according to general procedure BH using 5-{[(4-methoxy-2,6-dimethyl-benzenesulfonyl)-methyl-amino]-methyl}-furan-3-carboxylic acid (35 mg, 0.10 mmol), EDCI (27 mg, 0.14 mmol), HOBt (20 mg, 0.15 mmol), DIPEA (0.04 mL, 0.20 mmol), 1-(4-methylaminomethyl-benzyl)-azetidin-3-ol hydrochloride (29 mg, 0.11 mmol) and DCM (10 mL).

Sources & evidence

ORD record
ord-57c04c77e81a4d959a7d14ecd1cfd3d2
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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