1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 58392971, compound

HRID 469046Notes

Reaction equation

HRID 469046 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21](O)=[O:22])[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C.Cl.Cl.[CH3:57][O:58][CH:59]1[CH2:62][N:61]([CH2:63][C:64]2[CH:69]=[CH:68][C:67]([CH2:70][NH:71][CH3:72])=[CH:66][CH:65]=2)[CH2:60]1>C(Cl)Cl>[CH3:57][O:58][CH:59]1[CH2:62][N:61]([CH2:63][C:64]2[CH:69]=[CH:68][C:67]([CH2:70][N:71]([CH3:72])[C:21]([C:18]3[CH:17]=[C:16]([CH2:15][N:13]([S:10]([C:6]4[C:5]([CH3:24])=[CH:4][C:3]([O:2][CH3:1])=[CH:8][C:7]=4[CH3:9])(=[O:12])=[O:11])[CH3:14])[O:20][CH:19]=3)=[O:22])=[CH:66][CH:65]=2)[CH2:60]1

Participants

7

Reactant 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acidHCID 67217568HCID 67217568, compound

Product 1

HCID 58392971HCID 58392971, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared according to general procedure BH using 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (40 mg, 0.11 mmol), EDCI (29 mg, 0.15 mmol), HOBt (22 mg, 0.16 mmol), DIPEA (0.04 mL, 0.22 mmol), 1-{4-[(3-methoxyazetidin-1-yl)methyl]phenyl}-N-methylmethanamine dihydro chloride (35 mg, 0.13 mmol) and DCM (5 mL).

Sources & evidence

ORD record
ord-1cf03957985e4431811502f90b980712
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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