HRID469108

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16682925

Aluminum, trimethyl-

C3H9Al

HCID18525873

N-Methyl-1-{3-[(pyrrolidin-1-yl)methyl]phenyl}methanamine

C13H20N2

结构：COC(=O)c1nnc(CN(C)S(=O)(=O)c2c(C)cc(OC)cc2C)o1

HCID67217606

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C)c(S(=O)(=O)N(C)Cc2nnc(C(=O)N(C)Cc3cccc(CN4CCCC4)c3)o2)c(C)c1

HCID58393173

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound was prepared according to general procedure BK using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate (150 mg, 0.41 mmol), methyl-(3-pyrrolidin-1-ylmethyl-benzyl)-amine (99 mg, 0.48 mmol), trimethylaluminium (2 M in toluene, 0.44 mL) and THF (15 mL).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3445413d0b2d48219a34ced8eabc45cf
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08623859B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][C:19]([C:21](OC)=[O:22])=[N:18][N:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:25])[CH:4]=1.[CH3:26][NH:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH2:35][N:36]2[CH2:40][CH2:39][CH2:38][CH2:37]2)[CH:30]=1.C[Al](C)C>C1COCC1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][C:19]([C:21]([N:27]([CH3:26])[CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([CH2:35][N:36]4[CH2:40][CH2:39][CH2:38][CH2:37]4)[CH:30]=3)=[O:22])=[N:18][N:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:25])[CH:4]=1