反应详情

Under ice-cooling, 11.5 g of sodium triacetoxyborohydride was added in small portions to a solution of 4.0 g of 3,4,5-trifluoroaniline and 3.6 ml cyclopentanone in 150 ml dichloroethane and 3.1 ml acetic acid, and, after rising to room temperature, stirred for 3.5 hours. Aqueous saturated sodium hydrogen carbonate was added thereto, followed by extraction with chloroform and subsequent drying over anhydrous sodium sulfate. After filtration, the solvent was evaporated under a reduced pressure, and the resulting residue was purified by silica gel column chromatography to obtain 5.4 g of N-cyclopentyl-3,4,5-trifluoroaniline.

1. temperatureUnder ice-cooling
2. customafter rising to room temperature
3. extractionfollowed by extraction with chloroform
4. dry with materialsubsequent drying over anhydrous sodium sulfate
5. filtrationAfter filtration
6. customthe solvent was evaporated under a reduced pressure
7. customthe resulting residue was purified by silica gel column chromatography