HRID469303

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22293182

1-(Piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

C11H14N4O

结构：Cc1cc(C(=O)c2cc(Cl)ncn2)cc(C)c1OCc1ccccc1

HCID58181140

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)cc(C)c1OCc1ccccc1

HCID58181131

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

170 mg (0.779 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one, 270 mg (0.727 mmol) (4-benzyloxy-3,5-dimethyl-phenyl)-(6-chloro-pyrimidin-4-yl)-methanone and 0.200 mL (1.42 mmol) TEA were combined in 2.0 mL DMF and stirred overnight at RT. The reaction mixture was stirred into ice water, the precipitate was suction filtered and dried.

WORKUP

后处理

filtrationfiltered
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e22de6a59f8487f849ddb4b6c9ea5bb
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08629137B2
来源说明: uspto-grants-2014_01

反应 SMILES

[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.[CH2:17]([O:24][C:25]1[C:30]([CH3:31])=[CH:29][C:28]([C:32]([C:34]2[CH:39]=[C:38](Cl)[N:37]=[CH:36][N:35]=2)=[O:33])=[CH:27][C:26]=1[CH3:41])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C=O)C>[CH2:17]([O:24][C:25]1[C:26]([CH3:41])=[CH:27][C:28]([C:32]([C:34]2[N:35]=[CH:36][N:37]=[C:38]([N:1]3[CH2:2][CH2:3][CH:4]([N:7]4[C:15]5[C:10](=[N:11][CH:12]=[CH:13][CH:14]=5)[NH:9][C:8]4=[O:16])[CH2:5][CH2:6]3)[CH:39]=2)=[O:33])=[CH:29][C:30]=1[CH3:31])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1