Bms-973013 → HCID 58181131, compound

HRID 469303Notes

Reaction equation

HRID 469303 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.[CH2:17]([O:24][C:25]1[C:30]([CH3:31])=[CH:29][C:28]([C:32]([C:34]2[CH:39]=[C:38](Cl)[N:37]=[CH:36][N:35]=2)=[O:33])=[CH:27][C:26]=1[CH3:41])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C=O)C>[CH2:17]([O:24][C:25]1[C:26]([CH3:41])=[CH:27][C:28]([C:32]([C:34]2[N:35]=[CH:36][N:37]=[C:38]([N:1]3[CH2:2][CH2:3][CH:4]([N:7]4[C:15]5[C:10](=[N:11][CH:12]=[CH:13][CH:14]=5)[NH:9][C:8]4=[O:16])[CH2:5][CH2:6]3)[CH:39]=2)=[O:33])=[CH:29][C:30]=1[CH3:31])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 22293182Bms-973013HCID 58181140(4-Benzyloxy-3,5-dimethyl-phenyl)-(6-chloro-pyrimidin-4-yl)-methanone

Product 1

HCID 58181131HCID 58181131, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

170 mg (0.779 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one, 270 mg (0.727 mmol) (4-benzyloxy-3,5-dimethyl-phenyl)-(6-chloro-pyrimidin-4-yl)-methanone and 0.200 mL (1.42 mmol) TEA were combined in 2.0 mL DMF and stirred overnight at RT. The reaction mixture was stirred into ice water, the precipitate was suction filtered and dried.

Workup

  1. filtrationfiltered
  2. customdried

Sources & evidence

ORD record
ord-3e22de6a59f8487f849ddb4b6c9ea5bb
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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