反应详情

Under a nitrogen atmosphere 0.13 g (2.9 mmol) sodium hydride (55%, suspension in mineral oil) were added 0.90 g (2.8 mmol) 6-(2-chloro-6-methoxy-pyridine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one in 10 mL DMF at RT. The reaction mixture was stirred for 30 min at RT. Then 0.18 mL (5.0 mmol) iodomethane in 1 mL DMF were added dropwise and the mixture was stirred overnight at RT. The reaction mixture was poured onto water and the precipitate formed was suction filtered and washed with water. The residue was extracted with diethyl ether, suction filtered and dried.

1. stirringthe mixture was stirred overnight at RT
2. additionThe reaction mixture was poured onto water
3. customthe precipitate formed
4. filtrationfiltered
5. washwashed with water
6. extractionThe residue was extracted with diethyl ether, suction
7. filtrationfiltered
8. customdried