Hydrochloric Acid → HCID 178524638, compound

HRID 469355Notes

Reaction equation

HRID 469355 reaction equation
O.[Li+].[C:3]([O-:13])(=[O:12])[C:4]1[NH:11][C:9](=[O:10])[NH:8][C:6](=[O:7])[CH:5]=1.Cl>CN(C=O)C>[OH:10][C:9]1[N:11]=[C:4]([C:3]([OH:13])=[O:12])[CH:5]=[C:6]([OH:7])[N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46942246HCID 46942246, compound

Product 1

HCID 178524638HCID 178524638, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

23.00 g (127.74 mmol) orotic acid lithium salt monohydrate in 400 mL DMF were heated to 70° C. and at this temperature hydrochloric acid was added batchwise within 2 h. The reaction mixture was stirred for a further hour at 70° C. and then evaporated down in vacuo. The residue was stirred with water, suction filtered and dried at 50° C. in the CAD.

Workup

  1. additionwas added batchwise within 2 h
  2. customevaporated down in vacuo
  3. stirringThe residue was stirred with water, suction
  4. filtrationfiltered
  5. customdried at 50° C. in the CAD

Sources & evidence

ORD record
ord-1be5c6de24a64ec3af96f18b250350e0
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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