Methyl 3-amino-2-thiophenecarboxylate → HCID 58557000, compound

HRID 469451Notes

Reaction equation

HRID 469451 reaction equation
C([C:3](Br)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=[O:5])C.[NH2:14][C:15]1[CH:19]=[CH:18][S:17][C:16]=1[C:20]([O:22][CH3:23])=[O:21]>C(#N)C>[CH3:23][O:22][C:20]([C:16]1[S:17][CH:18]=[CH:19][C:15]=1[NH:14][CH:3]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:4]([OH:6])=[O:5])=[O:21]

Participants

4

Reactant 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 19431595Ethyl 2-bromo-2-phenylacetic acid

Product 1

HCID 58557000HCID 58557000, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of ethyl 2-bromo-2-phenylacetic acid (600 mg, 2.79 mmol) and methyl 3-aminothiophene-2-carboxylate (438 mg, 2.79 mmol) in acetonitrile (20 ml) was heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile was evaporated to dryness and the resulting residue was used in the next step without any further purification.

Workup

  1. customAcetonitrile was evaporated to dryness
  2. customthe resulting residue was used in the next step without any further purification

Sources & evidence

ORD record
ord-2852a2337e8d4caaa243ffaee22e39b6
Source dataset
uspto-grants-2014_01
Patent number
US08629160B2

Reaction notes

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