反应详情

A mixture of phenylboronic acid (286 mg, 2.35 mmol), methyl 3-aminothiophene-2-carboxylate (369 mg, 2.35 mmol), and 2-oxoacetic acid hydrate (216 mg, 2.35 mmol) in acetonitrile (20 ml) was stirred at room temperature for 2 hours. The reaction was filtered, and the precipitated was washed with little acetonitrile. The solution was concentrated under reduced pressure, and the precipitate was collected again by filtration, washing with little acetonitrile. The combined precipitates were dried under vacuum overnight to obtain 2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetic acid (558 mg, 82% yield).

1. filtrationThe reaction was filtered
2. washthe precipitated was washed with little acetonitrile
3. concentrationThe solution was concentrated under reduced pressure
4. filtrationthe precipitate was collected again by filtration
5. washwashing with little acetonitrile
6. customThe combined precipitates
7. customwere dried under vacuum overnight