反应详情

2-Bromo-1-(4-hydroxyphenyl)ethanone (54.8 mg, 0.25 mmol) was added portionwise to a solution of (R)-quinuclidin-3-yl 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate (C19) (100 mg, 0.25 mmol) in EtOAc (2 ml). The reaction mixture was stirred at room temperature overnight. The precipitate was filtered and washed with ethylacetate and then it was triturated with CH3CN to obtain (R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-(4-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (101 mg, 65.3% yield).

1. filtrationThe precipitate was filtered
2. washwashed with ethylacetate
3. customit was triturated with CH3CN