Dimethylamine → N,N,2-trimethyl-4-nitrobenzamide

Temperature

40 °C

A solution of 2 g (10.7 mmol) 2-methyl-4-nitro-benzoic acid, 1.32 ml (11.8 mmol) N-methyl-morpholine, 2.36 g (12 mmol) EDC-HCl and 2.36 g (12 mmol) HOBt in 50 ml dichloromethane is stirred at RT for 45 min, then dimethylamine solution (5.9 ml, 33% in EtOH) is added and the reaction mixture is heated to 40° C. and stirred at this temperature for 20 h. Another 1.32 ml (11.8 mmol) N-methyl-morpholine, 2.36 g (12 mmol) EDC-HCl and 2.36 g (12 mmol) HOBt (hydroxyl-benzotriazole) are added and stirred for 45 min, the again dimethylamine solution (5.9 ml, 33% in EtOH) is added and the reaction mixture is stirred at 40° C. for 35 h. After that the reaction mixture is cooled to RT and poured onto EtOAc/water. The organic layer is washed with sat. NAHCO3 solution and with water, dried over MgSO4, filtered and the filtrate is concentrated in vacuo. The residue is purified by chromatography (silicagel, hexane:EtOAc=1:1=>EtOAc) to afford the title compound as a yellowish oil.

1. stirringstirred for 45 min
2. stirringthe reaction mixture is stirred at 40° C. for 35 h
3. temperatureAfter that the reaction mixture is cooled to RT
4. additionpoured onto EtOAc/water
5. washThe organic layer is washed with sat. NAHCO3 solution and with water
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. concentrationthe filtrate is concentrated in vacuo
9. customThe residue is purified by chromatography (silicagel, hexane:EtOAc=1:1=>EtOAc)

ORD record

ord-d8cb48903bcf44e6be0d02e4f5871c0f

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08629168B2