反应详情

4-Amino-N-{4-[2-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-ethyl]-phenyl}-3-nitro-benzamide from above was dissolved in ethanol (25 ml) and 1N HCl (6 ml) to which was added 20% Pd(OH)2 and the mixture hydrogenated overnight under an atmosphere of hydrogen gas. The reaction was then filtered thru Celite and the filtrate evaporated to afford crude 3,4-Diamino-N-{4-[2-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-ethyl]-phenyl}-benzamide (1.18 g, 4×HCl salt) as a tan foam which was used as is in the next step.

1. customthe mixture hydrogenated overnight
2. filtrationThe reaction was then filtered thru Celite
3. customthe filtrate evaporated