HCID 59784811, compound → HCID 59784760, compound

HRID 470333Notes

Reaction equation

HRID 470333 reaction equation
NC1C(C(O)=O)=CN(C2N=CC3CC[C:14]4[CH:20]=[C:21]([O:24][CH3:25])C=C[C:13]=4[C:12]=3[N:11]=2)N=1.Br[C:27]1[CH:39]=[CH:38][C:30]2[NH:31]C(C(Cl)(Cl)Cl)=[N:33][C:29]=2[CH:28]=1>CC(N(C)C)=O>[NH2:33][C:29]1[CH:28]=[C:27]([C:20]2[C:21]([O:24][CH3:25])=[N:11][CH:12]=[CH:13][CH:14]=2)[CH:39]=[CH:38][C:30]=1[NH2:31]

Participants

4

Reactant 2

HCID 59784811HCID 59784811, compoundHCID 178478477HCID 178478477, compound

Product 1

HCID 59784760HCID 59784760, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of salicylaldehyde derivative 1 (0.5 mmol) and diamine 2 (0.176 g, 0.5 mmol) in dimethylacetamide (4 mL) was stirred at 100° C. for 12 h. Solvent was evaporated and the residue was purified by preparative HPLC to give benzimidazole derivative 3.

Workup

  1. customSolvent was evaporated
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-767a453eef514022b2180d55ee167413
Source dataset
uspto-grants-2014_01
Patent number
US08629147B2

Reaction notes

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