反应详情

温度

120 °C

A suspension of 4-bromo-2-methyl-6-nitroaniline (11.5 g, 50 mmol), Zn(CN)2 (770 mg, 150 mmol), and Pd(PPh3)4 (2.32 g, 2.0 mmol) in DMF (100 mL) was sealed and heated at 120° C. for 70 h. After cooled down to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was purified by chromatography with CH2Cl2 to afford the title compound (6.4 g, 73%). ESI-MS m/z 178 (MH+).

1. customwas sealed
2. temperatureAfter cooled down to room temperature
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. customThe residue was purified by chromatography with CH2Cl2