Hydrochloric Acid → HCID 86672599, compound

HRID 470684Notes

Reaction equation

HRID 470684 reaction equation
Cl.[C:2]([C@H:5]1[O:10][CH2:9][C@H:8]([NH:11][C:12]([C@@H:14]2[NH:28][C:27]3([CH2:33][CH2:32][C:31]([CH3:35])([CH3:34])[CH2:30][CH2:29]3)[C@:16]3([C:24]4[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=4)[NH:18][C:17]3=[O:26])[C@H:15]2[C:36]2[CH:41]=[CH:40][N:39]=[C:38]([Cl:42])[C:37]=2[F:43])=[O:13])[CH2:7][CH2:6]1)(=[O:4])[NH2:3]>CC(O)C>[OH2:4].[ClH:25].[C:2]([C@H:5]1[O:10][CH2:9][C@H:8]([NH:11][C:12]([C@@H:14]2[NH:28][C:27]3([CH2:29][CH2:30][C:31]([CH3:35])([CH3:34])[CH2:32][CH2:33]3)[C@:16]3([C:24]4[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=4)[NH:18][C:17]3=[O:26])[C@H:15]2[C:36]2[CH:41]=[CH:40][N:39]=[C:38]([Cl:42])[C:37]=2[F:43])=[O:13])[CH2:7][CH2:6]1)(=[O:4])[NH2:3].[CH3:2][CH:5]([OH:10])[CH3:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73297272Milademetan

Product 1

HCID 86672599HCID 86672599, compoundYield 152.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Concentrated hydrochloric acid (0.026 ml, 0.31 mmol) was added to a 2-propanol (2.0 ml) solution of the compound (192 mg, 0.31 mmol) obtained in Example 70 and the resulting mixture was dissolved by heating. After stirring at room temperature for 18 hours, the precipitate was collected by filtration to give 173 mg (85%) of the title compound as a solid.

Workup

  1. dissolutionthe resulting mixture was dissolved
  2. temperatureby heating
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-da9c2a3374344f5aa34784aeb5d324e6
Source dataset
uspto-grants-2014_01
Patent number
US08629133B2

Reaction notes

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