反应详情

tert-Butyldimethylsilyl chloride (6.45 g) was added to a stirred solution of 2-(2-fluorophenyl)ethanol (5.00 g) and 1H-imidazole (7.29 g) in dry DMF (30 mL) cooled in an ice bath. After 45 min, the reaction mixture was diluted with ethyl acetate, washed three times with water and evaporated in vacuo. The resulting gum was dissolved in isohexane and applied to a silica gel column eluting with isohexane followed by 1:3 ethyl acetate:isohexane to collect the product as an oil. Yield 9.0 g.

1. temperaturecooled in an ice bath
2. washwashed three times with water
3. customevaporated in vacuo
4. dissolutionThe resulting gum was dissolved in isohexane
5. washeluting with isohexane
6. customisohexane to collect the product as an oil