反应详情

tert-Butyldimethylsilyl chloride (3.19 g) was added to a solution of imidazole (3.6 g) and 3-(2-fluorophenyl)propan-1-ol (example 88, step a) (2.72 g) in dry DMF (30 mL) cooled in an ice bath. After 45 min, the reaction mixture was diluted with ethyl acetate (100 mL), washed with water (3×100 mL) and evaporated. The resulting gum was purified by silica gel chromatography eluting with isohexane. The fractions containing product were combined and evaporated to give the subtitled compound as a clear oil. Yield 4.4 g.

1. temperaturecooled in an ice bath
2. washwashed with water (3×100 mL)
3. customevaporated
4. customThe resulting gum was purified by silica gel chromatography
5. washeluting with isohexane
6. additionThe fractions containing product
7. customevaporated