反应详情

To a solution of 5-bromopentanol (10 g) in DCM (150 mL) was added pyridinium p-toluenesulfonate (1.5 g) followed by 3,4-dihydro-2H-pyran (8.1 mL) and the reaction mixture was stirred at room temperature under nitrogen for 21 hours. The solution was diluted with ether then washed with diluted brine (1:1 brine:water, 140 mL) before the organics were dried over sodium sulfate, filtered and evaporated. Purification was by silica gel chromatography eluting with 0 to 50% ethyl acetate in cyclohexane to afford the subtitled compound as a colourless liquid. Yield 14.14 g.

1. washthen washed with diluted brine (1:1 brine:water, 140 mL) before the
2. dry with materialorganics were dried over sodium sulfate
3. filtrationfiltered
4. customevaporated
5. customPurification
6. washeluting with 0 to 50% ethyl acetate in cyclohexane