Potassium Carbonate → 5-ethynyl-N-methylpyridin-2-amine

HRID 471403Notes

Reaction equation

HRID 471403 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][Si](C)(C)C)=[CH:5][N:4]=1.C([O-])([O-])=O.[K+].[K+]>CO>[C:9]([C:6]1[CH:7]=[CH:8][C:3]([NH:2][CH3:1])=[N:4][CH:5]=1)#[CH:10]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 66705950Methyl-(5-trimethylsilanylethynyl-pyridin-2-yl)-amine

Product 1

HCID 226631285-ethynyl-N-methylpyridin-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from 1.5 g (7.3 mmol) methyl-(5-trimethylsilanylethynyl-pyridin-2-yl)-amine and 507 mg (3.7 mmol) K2CO3 in 10 mL MeOH. Yield: 698 mg (56%) after chromatography on silica gel.

Sources & evidence

ORD record
ord-4abaf2844fc741e9ab769aaf5d22b918
Source dataset
uspto-grants-2014_01
Patent number
US08633183B2

Reaction notes

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