反应详情

4-Hydroxy-2-methoxybenzaldehyde (2.0 g, 13.15 mmol), benzyl bromide (3.14 mL, 26.3 mmol) and potassium carbonate (3.63 g, 26.3 mmol) are combined in acetone (5 mL) and the mixture is stirred for 4 hours. The mixture is concentrated under vacuum, suspended in dichloromethane and washed with water. The organic phase is concentrated under vacuum and the residue purified by flash chromatography (10% ethyl acetate in cyclohexane) to give the title compound (yield 2.0 g).

1. concentrationThe mixture is concentrated under vacuum
2. washwashed with water
3. concentrationThe organic phase is concentrated under vacuum
4. customthe residue purified by flash chromatography (10% ethyl acetate in cyclohexane)