反应详情

In a 20 mL microwave vial, 2-bromo-4-(trifluoromethyl)aniline (238 mg, 1 mmol) and copper cyanide (90 mg, 1 mmol) were dissolved in N-methylpyrrolidone (NMP) (10 mL). The reaction was placed in a microwave reactor for 5 minutes at 200° C. The crude was dissolved in ethyl acetate and the precipitate was removed by filtration. The clear solution was washed with water. The organic layer was collected, dried over sodium sulfate, and evaporated under vacuum. The residue was purified by Varia HPLC (10% acetonitrile/water) to give the title compound.

1. customthe precipitate was removed by filtration
2. washThe clear solution was washed with water
3. customThe organic layer was collected
4. dry with materialdried over sodium sulfate
5. customevaporated under vacuum
6. customThe residue was purified by Varia HPLC (10% acetonitrile/water)