Hydrogen Bromide → HCID 67481387, compound

HRID 472336Notes

Reaction equation

HRID 472336 reaction equation
[Br:1][C:2]1[C:3]2[N:4]([N:8]=[C:9](N)[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[BrH:12]>[Cu](Br)Br>[Br:12][C:9]1[N:10]=[C:3]2[C:2]([Br:1])=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 468640698-Bromo-(1,2,4)triazolo(1,5-a)pyridin-2-amine

Product 1

HCID 67481387HCID 67481387, compound

Reagents, catalysts & solvents 1

HCID 24611Copper bromide (CuBr2)Catalyst

Procedure

2,8-Dibromo-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (0.50 g, 2.3 mmol) with copper(II) bromide (0.140 g, 0.627 mmol) and 48% aqueous hydrobromic acid (5 mL, 40 mmol) in a manner analogous to Step 68a. the reaction product was isolated as a pale yellow solid (0.55 g, 85%). MP=150-151° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 8.99 (d, J=6.7 Hz, 1H), 8.08 (d, J=7.7 Hz, 1H), 7.20 (t, J=7.4 Hz, 1H). MS=276, 278, 280 (MH)+.

Sources & evidence

ORD record
ord-f8a541f6e2704c6f876a817e2cd37880
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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