反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 115 °C
PROCEDURE
实验过程
To a 2-5 ml microwave tube was added methyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (200 mg, 0.474 mmol), tetrakis(triphenylphosphine)palladium(0) (55 mg, 0.047 mmol), 2-(8-fluoro-5-methylchroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (180 mg, 0.616 mmol), DMF (3 mL), followed by 2M K2CO3 solution (300 μl). The reaction mixture was heated in a microwave reactor at 115° C. for 45 min. The reaction mixture was filtered and the filtrate was purified by silica gel chromatography to afford (128 mg, 48.9%) of the title compound. 1H NMR (400 MHz, CHLOROFORM-d) δ 7.82 (s, 1H), 7.76-7.65 (m, 1H), 7.41-7.29 (m, 2H), 7.01-6.73 (m, 2H), 5.02 (s, 1H), 4.37 (dt, J=6.5, 3.5 Hz, 2H), 3.66 (s, 3H), 2.93-2.69 (m, 5H), 2.21 (dd, J=5.6, 2.4 Hz, 2H), 1.86 (s, 3H), 1.18 (s, 9H).
WORKUP
后处理
- filtrationThe reaction mixture was filtered
- customthe filtrate was purified by silica gel chromatography