Methyl (4-{[(4,4-difluorocyclohexyl)methyl]amino}-3-nitrophenyl)carbamate → HCID 57723210, compound

HRID 472947Notes

Reaction equation

HRID 472947 reaction equation
[F:1][C:2]1([F:24])[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:20])[O:18][CH3:19])=[CH:12][C:11]=2[N+:21]([O-])=O)[CH2:4][CH2:3]1>CCOC(C)=O.[Pd]>[NH2:21][C:11]1[CH:12]=[C:13]([NH:16][C:17](=[O:20])[O:18][CH3:19])[CH:14]=[CH:15][C:10]=1[NH:9][CH2:8][CH:5]1[CH2:6][CH2:7][C:2]([F:24])([F:1])[CH2:3][CH2:4]1

Participants

4

Reactant 1

HCID 57723212Methyl (4-{[(4,4-difluorocyclohexyl)methyl]amino}-3-nitrophenyl)carbamate

Product 1

HCID 57723210HCID 57723210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Following the same procedure as in Step D of Example 4 using methyl (4-{[(4,4-difluorocyclohexyl)methyl]amino}-3-nitrophenyl)carbamate (200 mg, 0.583 mmol) and a catalytic amount of 10% Pd/C in 20 mL of EtOAc. Yield: 185 mg (99%). MS (ESI) (M+H)+ 314.29.

Sources & evidence

ORD record
ord-3edb10d63be44ae1b7e97e2cc64738e4
Source dataset
uspto-grants-2014_01
Patent number
US08633235B2

Reaction notes

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