反应详情

18 g of hexamethylene tetramine was added little by little to a mixture of 31 g N-(4-methoxybenzyl)phthalimide and 100 ml trifluoroacetic acid, stirred at room temperature for 1 hr, and then heated under reflux for 4 hr. The reaction solution was cooled to 0° C., and water was added thereto. Potassium carbonate was added thereto and the resulting crystals were collected by filtration. The crystals were dried to give 20 g of N-(3-formyl-4-methoxybenzyl)phthalimide.

1. temperatureheated
2. temperatureunder reflux for 4 hr
3. temperatureThe reaction solution was cooled to 0° C.
4. filtrationthe resulting crystals were collected by filtration
5. customThe crystals were dried