反应详情

温度

60 °C

A mixture of N-(5-(chloromethyl)-2,3-dihydro-1H-inden-1-yl)propane-2-sulfonamide (30 mg, 0.104 mmol), 2-(trifluoromethyl)phenol (16.90 mg, 0.104 mmol), and potassium carbonate (28.8 mg, 0.208 mmol) in N,N-dimethylformamide (1 mL) was stirred at 60° C. overnight. The reaction mixture was partitioned between aq. sat. NaHCO3 (4 mL) and DCM (4 mL), filtered over a phase separator, and the organic phase was concentrated by blow down. Purification by flash chromatography (0-60% EtOAc in Heptane) and freeze drying from acetonitrile/water gave the title compound as a white solid (24 mg, 55.7%). MS (ESI): m/z [M−H]− 412.0.

1. customThe reaction mixture was partitioned between aq. sat. NaHCO3 (4 mL) and DCM (4 mL)
2. filtrationfiltered over a phase separator
3. concentrationthe organic phase was concentrated by blow down
4. customPurification by flash chromatography (0-60% EtOAc in Heptane)
5. dry with materialfreeze drying from acetonitrile/water