Phosphorus oxychloride → 4-Chloro-2-(difluoro(5-fluoropyridin-2-yl)methyl)-8-fluoroquinazoline
Reaction equation
[F:1][C:2]([F:22])([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][N:16]=1)[C:3]1[NH:12][C:11](=O)[C:10]2[C:5](=[C:6]([F:14])[CH:7]=[CH:8][CH:9]=2)[N:4]=1.CCN(C(C)C)C(C)C.P(Cl)(Cl)([Cl:34])=O>>[Cl:34][C:11]1[C:10]2[C:5](=[C:6]([F:14])[CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]([C:2]([F:22])([F:1])[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][N:16]=2)[N:12]=1Participants
Conditions
- Temperature
- 115 °C
Procedure
To 2-(difluoro(5-fluoropyridin-2-yl)methyl)-8-fluoroquinazolin-4(3H)-one (309 mg, 1.0 mmol) were added DIEA (0.36 mL, 2.0 mmol) and phosphorous oxychloride (7.0 mL, 76 mmol, and the mixture was heated at 115° C. for 6 h. The mixture was allowed to cool to rt and then was concentrated under reduced pressure. Toluene was added and evaporated twice to remove residual phosphorous oxychloride. The residue was partitioned between EtOAc (20 mL) and cold saturated aq NaHCO3 (10 mL). The separated EtOAc layer was diluted with EtOAc (60 mL) and washed with saturated aq NaHCO3 (10 mL) and brine (2×10 mL), dried over MgSO4, filtered, and concentrated under reduced pressure to afford 4-chloro-2-(difluoro(5-fluoropyridin-2-yl)methyl)-8-fluoroquinazoline as a brown viscous oil (222 mg).
Workup
- temperatureto cool to rt
- concentrationwas concentrated under reduced pressure
- additionToluene was added
- customevaporated twice
- customto remove residual phosphorous oxychloride
- customThe residue was partitioned between EtOAc (20 mL) and cold saturated aq NaHCO3 (10 mL)
- additionThe separated EtOAc layer was diluted with EtOAc (60 mL)
- washwashed with saturated aq NaHCO3 (10 mL) and brine (2×10 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-17d12b4a756d455e900f59a57567580e
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08633207B2
Reaction notes
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