反应详情

To sodium 2,2-difluoro-2-(5-fluoropyridin-2-yl)acetate from Example 2 step B (1 g, 4.69 mmol) were added EtOAc (50 mL) and 4 N HCl (50 mL) and the mixture was shaken. The organic phase was separated, dried over sodium sulfate, and concentrated under reduced pressure to afford 2,2-difluoro-2-(5-fluoropyridin-2-yl)acetic acid (852 mg, 95%) as an oil that solidified upon standing. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.88-8.03 (m, 3H).

1. customThe organic phase was separated
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated under reduced pressure