反应详情

5 ml N,N-dimethylformamide was added to a mixture of 12.7 g 1-benzyl-4-piperidine carboxamide and 60 ml phosphorus oxychloride under ice-cooling, and it was stirred at room temperature for 1.5 hr. It was evaporated, and the resulting residue was dissolved in ethyl acetate and washed with aqueous sodium hydroxide and brine. After drying over anhydrous sodium sulfate, it was evaporated, and the resulting residue was purified by silica gel column chromatography to give 11.0 g of 1-benzyl-4-piperidine carbonitrile.

1. temperaturecooling
2. customIt was evaporated
3. dissolutionthe resulting residue was dissolved in ethyl acetate
4. washwashed with aqueous sodium hydroxide and brine
5. dry with materialAfter drying over anhydrous sodium sulfate, it
6. customwas evaporated
7. customthe resulting residue was purified by silica gel column chromatography