反应详情

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid (126 mg) was suspended in 2-propanol (2.0 mL) at 40° C. with magnetic stirring. Hydrochloric acid (284 μL, 1 N) was diluted with 2-propanol (216 μL). Hydrochloric acid solution was then slowly added to A-968660 free base suspension at 40° C. with magnetic stirring. Crystallization was observed shortly after the complete addition of the HCl solution. Solid was collected by centrifuge filtration.

1. customCrystallization
2. additionafter the complete addition of the HCl solution
3. filtrationSolid was collected by centrifuge filtration