反应详情

温度

25 °C

1,1-Dimethylethyl (3S)-3-fluoro-3-({[(trifluoromethyl)sulfonyl]oxy}methyl)-1-piperidinecarboxylate (1 wt) is dissolved in N,N,-dimethylformamide (3 vol) at 20° C. and sodium azide (1.1 eq, 0.20 wt) is added. The resulting suspension is stirred at 20-30° C. for 6 h. TBME (5 vol) and water (9 vol) are added. The mixture is stirred for 5 min and the layers are separated. The aqueous phase is extracted with TBME (5 vol) and the TBME phases are combined. The combined organics are washed with water (2×5 vol), filtered and concentrated under reduced pressure to give the title compound as an orange oil.

1. stirringThe mixture is stirred for 5 min
2. customthe layers are separated
3. extractionThe aqueous phase is extracted with TBME (5 vol)
4. washThe combined organics are washed with water (2×5 vol)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure