Azobisisobutyronitrile → 2-Bromomethyl-3-methoxybenzoic acid

HRID 473463Notes

Reaction equation

HRID 473463 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH3:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=[O:7].C1C(=O)N([Br:20])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>ClC1C=CC=CC=1>[Br:20][CH2:12][C:4]1[C:3]([O:2][CH3:1])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Participants

5

Reactant 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 70214833-Methoxy-2-MethylBenzoic Acid

Product 1

HCID 570588912-Bromomethyl-3-methoxybenzoic acid

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

for the synthesis of the title compound, 6.64 g (0.040 mol) of 3-methoxy-2-methylbenzoic acid, 7.1 g (0.040 mol) of NBS and 0.25 g of AIBN in 150 ml of chlorobenzene are reacted by method H (variant 1).

Sources & evidence

ORD record
ord-79c979a2b820446bb05861b3ac9a39bc
Source dataset
uspto-grants-2014_01
Patent number
US08633312B2

Reaction notes

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