反应详情

For the synthesis of the title compound, 0.52 g (0.0020) mol of 8-chloro-1-hydroxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one, 0.26 g (0.0020 mol) of 2,4-difluoroaniline, 2 spatula tips of Pd(OAc)2, 0.14 g of phosphine ligand and 0.90 g (0.0094 mol) of NaOtert-Bu in 10 ml of toluene and 2 ml of tert-BuOH are reacted by method O. Purification is carried out by column chromatography (flash; silica gel, 90% hexane+10% ethyl acetate). C21H15F2NO2 (Mr=351.36); GC 35.3 min