Stannous chloride dihydrate → 8-Amino-3-(4-fluoro-2-methoxyphenylamino)-6H-dibenzo[b,e]oxepin-11-one

HRID 473493Notes

Reaction equation

HRID 473493 reaction equation
O.O.[Sn](Cl)Cl.[N+:6]([C:9]1[CH:34]=[CH:33][C:12]2[C:13](=[O:32])[C:14]3[CH:21]=[CH:20][C:19]([NH:22][C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=4[O:30][CH3:31])=[CH:18][C:15]=3[O:16][CH2:17][C:11]=2[CH:10]=1)([O-])=O>C(O)C>[NH2:6][C:9]1[CH:34]=[CH:33][C:12]2[C:13](=[O:32])[C:14]3[CH:21]=[CH:20][C:19]([NH:22][C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=4[O:30][CH3:31])=[CH:18][C:15]=3[O:16][CH2:17][C:11]=2[CH:10]=1

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 673606278-Nitro-3-(4-fluoro-2-methoxyphenylamino)-6H-dibenzo[b,e]oxepin-11-one

Product 1

HCID 452807448-Amino-3-(4-fluoro-2-methoxyphenylamino)-6H-dibenzo[b,e]oxepin-11-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In accordance with general method Y, 0.30 g (1.32 mmol) of tin(II) chloride dihydrate is dissolved in 15 ml of ethanol, and 0.07 g (0.19 mmol) of (16) is added. Yield: 0.042 g (60.6%); melting point: 38.9° C.; C21H17FN2O3 (Mr=364.38); LC 18.82 min

Workup

  1. customLC 18.82 min

Sources & evidence

ORD record
ord-e01bfe619b4f420993fcbc4aefaeb3d6
Source dataset
uspto-grants-2014_01
Patent number
US08633312B2

Reaction notes

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