反应详情

To a solution of 500 mg (1.6 mmol, 1 equiv.) of 4-dibenzylamino-butyric acid ethyl ester in 1 ml of THF was added 4 ml of HCl 2N and the resulting mixture was stirred for 48 hours. After decantation and separation, the aqueous layer was extracted twice by ethyl acetate. The pH was fixed to 5 using solid sodium carbonate and the aqueous layer was extracted by dichloromethane. The dichloromethane layer was dried over sodium sulphate, evaporated and used without further purification.

1. customAfter decantation and separation
2. extractionthe aqueous layer was extracted twice by ethyl acetate
3. extractionthe aqueous layer was extracted by dichloromethane
4. dry with materialThe dichloromethane layer was dried over sodium sulphate
5. customevaporated
6. customused without further purification