反应详情

To a round-bottomed flask was added 2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine (1.1754 g, 6.52 mmol) and palladium hydroxide on carbon (0.458 g, 0.652 mmol) in EtOAc (21.75 mL). The reaction mixture was flushed with argon and then placed under vacuum three times. A hydrogen balloon was then attached to the reaction. After stirring overnight, the reaction mixture was filtered through celite and concentrated in vacuo to give the title compound. MS (ESI, pos. ion) m/z: 183.1.

1. customThe reaction mixture was flushed with argon
2. customA hydrogen balloon was then attached to the reaction
3. filtrationthe reaction mixture was filtered through celite and
4. concentrationconcentrated in vacuo