Trifluoroacetic acid → HCID 10272693, compound

HRID 47379Notes

Reaction equation

HRID 47379 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[C:17]([C:21]1[CH:28]=[CH:27][C:24](C=C)=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18].F[C:30](F)(F)[C:31](O)=O>C(#N)C>[CH2:30]([O:15][C:13]([CH:12]1[CH2:10][CH:11]([C:24]2[CH:23]=[CH:22][C:21]([C:17]([CH3:19])([CH3:18])[CH3:20])=[CH:28][CH:27]=2)[C:3]2[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=2[Cl:1])[NH:5]1)=[O:14])[CH3:31]

Participants

6

Reactant 4

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 156274-tert-ButylstyreneHCID 35932772-Ketobutyrate

Product 1

HCID 10272693HCID 10272693, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Compound 25 was prepared in a yield of 89% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-tert-butylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

Sources & evidence

ORD record
ord-f4ad772de6f74ca6bcc349827957c250
Source dataset
uspto-grants-2004_03
Patent number
US06699877B2

Reaction notes

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