反应详情

温度

90 °C

A mixture of 2-amino-5-bromo-3-nitropyridine (0.70 g, 3.2 mmol), (4-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)boronic acid (example 1, step 2) (1.0 g, 3.1 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane (0.15 mg, 0.2 mmol), diisopropylethylamine (1.8 g, 14 mmol) in 50% aqueous 1,4-dioxane (40 mL) was degassed with nitrogen for 5 minutes and then stirred at 90° C. for one hour. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (80 mL) then filtered over celite. The filtrate was washed twice with brine (50 mL), filtered and the filtrate dried over sodium sulfate, filtered again and concentrated. The residue was purified by silica gel chromatography (25% to 95% ethyl acetate in hexanes gradient) to give 1,1-dimethylethyl 7-(6-amino-5-nitropyridin-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (0.58 g, 48% yield); MS (EI) for C19H22N4O5: 389 (MH+).

1. customwas degassed with nitrogen for 5 minutes
2. temperatureThe reaction mixture was cooled to room temperature
3. additiondiluted with ethyl acetate (80 mL)
4. filtrationthen filtered over celite
5. washThe filtrate was washed twice with brine (50 mL)
6. filtrationfiltered
7. dry with materialthe filtrate dried over sodium sulfate
8. filtrationfiltered again
9. concentrationconcentrated
10. customThe residue was purified by silica gel chromatography (25% to 95% ethyl acetate in hexanes gradient)