Hydrochloric Acid → Sodium Chloride

HRID 474120Notes

Reaction equation

HRID 474120 reaction equation
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+:19].[ClH:20].C1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[N:9]=1.[Cl-:20].[Na+:19]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 14798Sodium HydroxideHCID 68108403HCID 68108403, compound

Product 2

HCID 5234Sodium ChlorideHCID 68107873HCID 68107873, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-amino-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester (400 mg, 1.59 mmol) in 20 ml THF was added 2.5 ml (2.5 mmol) 1N sodium hydroxide and the mixture was stirred at room temperature over night. To the mixture were added (2.39 ml, 2.39 mmol) 1N HCl after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as an off-white solid. The mixture was used for coupling reactions without further purification.

Workup

  1. additionwas added
  2. customthe solvents were evaporated

Sources & evidence

ORD record
ord-a629146b54a145718fce08ff17f43b43
Source dataset
uspto-grants-2014_01
Patent number
US08637508B2

Reaction notes

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