反应详情

Piperazine (107.5 g, 1.25 mole) was dissolved in DCM (500 ml). Trityl chloride (69.7 g, 0.25 mole) was added to the mixture cooled in an ice bath. After addition, the mixture was kept at room temperature for 30 min. The mixture was washed with water (500 ml, three times). And the organic layer was separated and dried over sodium sulfate. The mixture was concentrated to ca. 100 ml and added to hexane (1 liter). The solid was removed by filtration. The filtrate was evaporated to dryness to give a white solid (ca. 100 g).

1. temperaturecooled in an ice bath
2. additionAfter addition
3. washThe mixture was washed with water (500 ml, three times)
4. customAnd the organic layer was separated
5. dry with materialdried over sodium sulfate
6. concentrationThe mixture was concentrated to ca. 100 ml
7. additionadded to hexane (1 liter)
8. customThe solid was removed by filtration
9. customThe filtrate was evaporated to dryness