反应详情

温度

100 °C

8-Bromo-2-methylquinoline4-carboxylic acid ethyl ester (0.5 g), lithium chloride (0.216 g), tetraethyltin (0.435 g) and bis(triphenylphosphine)palladium (II) chloride (0.05 g) were combined in dimethylformamide (20 ml) and heated at 100° C. for 24 h. Solvent was removed at reduced pressure, the residue dissolved in dichloromethane and filtered. Solvent was removed at reduced pressure and the residue column chromatographed (silica gel, 5% diethyl ether/pentane) to give the title compound (0.215 g). m/z (API+): 244 (MH+).

1. customSolvent was removed at reduced pressure
2. dissolutionthe residue dissolved in dichloromethane
3. filtrationfiltered
4. customSolvent was removed at reduced pressure
5. customthe residue column chromatographed (silica gel, 5% diethyl ether/pentane)