反应详情

温度

140 °C

K2CO3 (23.45 g, 170 mmol) was added to a solution of 3-(trifluoromethyl)phenol (25 g, 154 mmol) and 4-fluorobenzaldehyde (19.14 g, 154 mmol) in DMF (300 mL), and the reaction mixture was stirred at 140° C. for 4 h. After cooling down to room temperature, the reaction mixture was poured into ice water (2500 ml), extracted with ethyl acetate (500 ml×2), and washed with brine (200 mL×2). The organic phase was dried with sodium sulfate, filtered, and concentrated to give the title compound as a brown solid (35 g, 66.9% yield). LCMS: rt=1.62 min, [M+H+]=267

1. temperatureAfter cooling down to room temperature
2. extractionextracted with ethyl acetate (500 ml×2)
3. washwashed with brine (200 mL×2)
4. dry with materialThe organic phase was dried with sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated