HRID474786
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 160 °C
PROCEDURE
实验过程
To the suspension of ethyl (2Z)-2-ethyl-3-hydroxy-2-propenoate (281 mg, 1.951 mmol) and K2CO3 (270 mg, 1.951 mmol) in NMP (10 mL) was added 2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate (350 mg, 0.976 mmol). The reaction mixture was heated with a microwave reactor at 160° C. for 1.5 h. Purification via MDAP then afforded the title compound (165 mg, 38.5% yield). LCMS: rt=3.89 min, [M+H+]=439
WORKUP
后处理
- customPurification via MDAP